2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12149
    A-867744 1000279-69-5 99.76%
    A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.
    A-867744
  • HY-12501
    ITI-214 free base 1160521-50-5 ≥98.0%
    ITI-214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 free base inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 free base shows efficacy in various animal models of motor and cognitive functions.
    ITI-214 free base
  • HY-12503
    CFM-2 178616-26-7 98.93%
    CFM-2 is a potent and selective non-competitive AMPAR antagonist. CFM-2 possesses anticonvulsant activity in various models of seizures.
    CFM-2
  • HY-12688
    Succinyl phosphonate 26647-82-5 98%
    Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
    Succinyl phosphonate
  • HY-12840
    OBA-09 856095-68-6 99.17%
    OBA-09, a simple ester of pyruvate and salicylic acid, is potent multi-modal neuroprotectant. OBA-09 has anti-oxidative and anti-inflammatory effects.
    OBA-09
  • HY-12962
    NMDA-IN-1 700878-19-9 98.98%
    NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.
    NMDA-IN-1
  • HY-13201
    CGS 21680 120225-54-9 98%
    CGS 21680 is a selective adenosine A2A receptor agonist, with a Ki of 27 nM.
    CGS 21680
  • HY-13239
    LY2979165 1311385-32-6 98.10%
    LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.
    LY2979165
  • HY-14567
    Ciproxifan 184025-18-1 99.26%
    Ciproxifan (FUB 359) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan displays low apparent affinity at other receptor subtypes. Ciproxifan can be used for the research of aging disorders and Alzheimer's disease.
    Ciproxifan
  • HY-14825
    Tarafenacin 385367-47-5 98%
    Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.
    Tarafenacin
  • HY-14895
    Fabomotizole 173352-21-1 99.96%
    Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects.
    Fabomotizole
  • HY-15073
    Becampanel 188696-80-2 ≥98.0%
    Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.
    Becampanel
  • HY-15393
    VU 0357121 433967-28-3 99.73%
    VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes.
    VU 0357121
  • HY-15394
    (Rac)-Rotigotine hydrochloride 102120-99-0 98.11%
    (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
    (Rac)-Rotigotine hydrochloride
  • HY-15430
    Encenicline 550999-75-2 98%
    Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
    Encenicline
  • HY-15560
    Hoechst 34580 23555-00-2 99.84%
    Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution.
    Hoechst 34580
  • HY-15736
    Sodium Channel inhibitor 1 1198117-23-5 99.38%
    Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
    Sodium Channel inhibitor 1
  • HY-16687
    Eltoprazine 98224-03-4
    Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine shows antiaggressive and anxiogenic effects.
    Eltoprazine
  • HY-16713
    (S)-(-)-5-Fluorowillardiine 140187-23-1 98%
    (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.
    (S)-(-)-5-Fluorowillardiine
  • HY-42225
    Methyl 7α-hydroxy-3-ketocholanoate 14773-00-3 99.94%
    Methyl 7α-hydroxy-3-ketocholanoate is a bile acid compound that can be used in neurological disease research.
    Methyl 7α-hydroxy-3-ketocholanoate
Cat. No. Product Name / Synonyms Application Reactivity